Article

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

2023-05-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims</h4> Chemotherapies such as gemcitabine/nab-paclitaxel are confronted with intrinsic or acquired resistance in pancreatic ductal adenocarcinoma (PDAC). We aimed to identify novel actionable mechanisms to overcome such resistance. <h4>Methods</h4> Three paclitaxel (PR) and gemcitabine resistant (GR) PDAC models were established. Transcriptomics and proteomics were used to identify cons...

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Literature Corpus work: a05b3940-d5be-5194-9a9a-7b34f9516296
DOI: 10.1101/2023.05.30.542412

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