Article
Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
2020-07-17
Abstract excerpt
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that the NRF2 anti-oxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) and the clinically approved dimethyl fumarate (DMF) induce a cel...
Topics
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- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Phytochemicals and Antioxidant Activities
- Respiratory viral infections research
Identifiers and source
- Literature Corpus work
- a019a8b1-19aa-5e93-97b4-0544e88ee9ec
- DOI
- 10.1101/2020.07.16.206458