Article

NRF2 activators restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1

2025-02-24

Abstract excerpt

Nuclear factor erythroid 2–related factor 2 (NRF2) is a master regulator of anti-oxidative and detoxifying cell responses. In addition, it plays important roles in host cell defenses against pathogenic viruses, and small molecules that activate NRF2 signaling can exert potent antiviral effects. We recently found that the NRF2 activators 4-octyl itaconate (4OI), bardoxolone (BARD), and sulforaphane (SFN) interfere...

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Literature Corpus work: 91eb4c4c-2554-569f-9920-0518faab4ea2
DOI: 10.1101/2025.02.24.639813

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