Article

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response

2020-09-08

Abstract excerpt

Here we have analyzed the dynamics of the adaptive immune response triggered by SARS-CoV-2 in severely affected COVID-19 patients, as reflected by activated B cells egressing into the blood, at the single cell level. Early on, before seroconversion in response to SARS-CoV-2 spike protein, activated peripheral B cells displayed a type 1 interferon-induced gene expression signature. After seroconversion, activated B...

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Literature Corpus work: a0054e38-9530-564b-9362-b8a0cb56721e
DOI: 10.1101/2020.09.04.20188169

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