Article
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.
Science immunology - 26 Jun 2020
Weiskopf Daniela, Schmitz Katharina S, Raadsen Matthijs P, Grifoni Alba, Okba Nisreen M A, Endeman Henrik, van den Akker Johannes P C, Molenkamp Richard, Koopmans Marion P G, van Gorp Eric C M, Haagmans Bart L, de Swart Rik L, Sette Alessandro, de Vries Rory D
Abstract excerpt
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory tract disease (COVID-19). In some patients the infection results in moderate to severe acute respiratory distress syndrome (ARDS), requiring invasive mechanical ventilation. High serum levels of IL-6, IL-10 and an immune hyperresponsiveness referred to as a 'cytokine storm' have been associated with poor clinical outcome....
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