Article

Maturing neutrophils of lower density associate with thrombocytopenia in Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome

2024-02-22

Abstract excerpt

Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome (PUUV-HFRS) is characterized by strong neutrophil activation. Neutrophils are the most abundant immune cell type in the circulation and are specially equipped to rapidly respond to infections. They are more heterogenous than previously appreciated, with specific neutrophil subsets recently implicated in inflammation and immunosuppression. Further...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e9ed7ad-27b2-5bba-adf6-5eb0558a2975
DOI: 10.1101/2024.02.19.580937

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Maturing neutrophils of lower density associate with thrombocytopenia in Puumala orthohantavirus-caused hemorrhagic fever with renal syndromeDOI 10.1101/2024.02.19.580937Read

Multi-Omics Profiling Reveals Phenotypic and Functional Heterogeneity of Neutrophils in COVID-19.Semantic proximity Read

Characterizing a Low-Density Neutrophil gene signature in acute and chronic infections and its impact on disease severitySemantic proximity Read

Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in COVID-19Semantic proximity Read

ScRNA-Seq study of neutrophils reveals vast heterogeneity and breadth of inflammatory responses in severe COVID-19 patientsSemantic proximity Read

Heterogeneity of neutrophils and inflammatory responses in patients with COVID-19 and healthy controlsSemantic proximity Read

Innate lymphoid cells are activated and their levels correlate with viral load in patients with Puumala hantavirus caused hemorrhagic fever with renal syndromeSemantic proximity Read

IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infectionsSemantic proximity Read

Impairment of Neutrophil Functions and Homeostasis in COVID-19 Patients: Association With Disease SeveritySemantic proximity Read

Longitudinal Characterization of Circulating Neutrophils Uncovers Distinct Phenotypes Associated with Disease Severity in Hospitalized COVID-19 PatientsSemantic proximity Read

Novel neutrophil biology insights underlying atypical chemokine receptor-1/Duffy antigen receptor of chemokines-associated neutropeniaSemantic proximity Read

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patientsSemantic proximity Read

Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype.Semantic proximity Read