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9-Gene Signature Correlated With CD8+ T Cell Infiltration Activated by IFN-γ: A Biomarker of Immune Checkpoint Therapy Response in Melanoma

17 Jun 2021

Abstract excerpt

Purpose To identify CD8+T cell-related factors and the co-expression network in melanoma and illustrate the interactions among CD8+T cell-related genes in the melanoma tumor microenvironment. Method We obtained melanoma and paracancerous tissue mRNA matrices from TCGA-SKCM and GSE65904. The CIBERSORT algorithm was used to assess CD8+T cell proportions, and the “estimate” package was used to assess melanoma tumor...

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PMID: 34220795
DOI: 10.3389/fimmu.2021.622563

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