Article

Chronic intermittent nicotine delivery with lung alveolar region-targeted aerosol technology produces circadian blood pharmacokinetics in rats resembling human smokers

2017-09-27

Abstract excerpt

<h4>Introduction</h4> Cigarette smoke is an aerosol containing microparticles that carry nicotine into lung alveolar region where nicotine is rapidly absorbed into circulation. Nicotine exposure in smokers is a chronic intermittent process, with intake during wakefulness and abstinence during sleep resulting in circadian fluctuation of blood nicotine levels. Here we present a smoking-relevant nicotine exposure de...

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Literature Corpus work: 9e876359-a344-506e-938a-b034ba3e28b2
DOI: 10.1101/195123

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