Article

Immune profiling of cord blood after prolonged rupture of membranes

2018-10-16

Abstract excerpt

We hypothesised that foetal immune responses to an infectious challenge may be detected by genome-wide transcriptional profiling of cord blood. In order to test this hypothesis, we sought to identify transcriptomic changes in post-natal cord blood samples following prolonged pre-labour rupture of membranes (PROM) as a surrogate for increased risk of infection. By comparison to controls we found increased levels of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e786283-e6b1-56bf-9f78-5485e564dffc
DOI: 10.1101/444216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune profiling of cord blood after prolonged rupture of membranesDOI 10.1101/444216Read

The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type IISemantic proximity Read

Umbilical cord gene expression reveals the molecular architecture of the fetal inflammatory response in extremely preterm newbornsSemantic proximity Read

Immune cell and transcriptomic analysis of the human decidua in term and preterm parturitionSemantic proximity Read

ORIGINAL ARTICLE: The Transcriptome of the Fetal Inflammatory Response SyndromeSemantic proximity Read

Placental Inflammation in Preterm Premature Rupture of Membranes and Risk of Neurodevelopmental DisordersSemantic proximity Read

CD8+ T cells in fetal membranes display a unique phenotype, and their activation is involved in the pathophysiology of spontaneous preterm birth.Semantic proximity Read

Genome and transcriptome profiling of spontaneous preterm birth phenotypesSemantic proximity Read

Rapid immune perturbations during sepsis and necrotising enterocolitis in preterm babiesSemantic proximity Read

Transcriptomics reveals preterm birth risk: identification and validation of key genes in monocytesSemantic proximity Read

RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic InfectionSemantic proximity Read

Replicated umbilical cord blood DNA methylation loci associated with gestational age at birthSemantic proximity Read

Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birthSemantic proximity Read