Article

Bisbee: A proteomics validated analysis package for detecting differential splicing, identifying splice outliers, and predicting splice event protein effects

2020-08-14

Abstract excerpt

Here we present a novel statistical approach to splicing outlier and differential splicing detection, implemented in a software package called Bisbee. We leverage Bisbee’s prediction of protein level effects to benchmark using matched RNAseq and mass spectrometry data from normal tissues. Bisbee exhibits improved sensitivity and specificity over existing approaches. We applied Bisbee to confirm a pathogenic splici...

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Literature Corpus work: 9dd6e553-d660-5ce9-8564-7f41db5d1e89
DOI: 10.1101/2020.08.13.250167

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