Article

A mutation rate model at the basepair resolution identifies the mutagenic effect of Polymerase III transcription

2022-08-21

Abstract excerpt

De novo mutations occur with substantially different rates depending on genomic location, sequence context and DNA strand 1–4 . The success of many human genetics techniques, especially when applied to large population sequencing datasets with numerous recurrent mutations 5–7 , depends strongly on assumptions about the local mutation rate. Such techniques include estimation of selection intensity 8 , inference...

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Literature Corpus work: 9db0a3f8-2645-5143-9fce-9924d83f2201
DOI: 10.1101/2022.08.20.504670

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