Article

A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation

2019-06-21

Abstract excerpt

Spinal Muscular Atrophy (SMA) is the most common genetic disease in childhood. SMA is generally caused by mutations in SMN1 . The Survival of Motor Neurons (SMN) complex consists of SMN1, Gemins (2–8) and Strap/Unrip. We previously demonstrated smn1 and gemin5 inhibited tissue regeneration in zebrafish. Here we investigated each individual SMN complex member and identified gemin3 as another regeneration-essent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c5ef9b1-eca8-528e-a768-8a18b1135956
DOI: 10.1101/678417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferationDOI 10.1101/678417Read

Transcriptome Profiling of Spinal Muscular Atrophy Motor Neurons Derived from Mouse Embryonic Stem CellsSemantic proximity Read

Whole-transcriptome sequencing in neural and non-neural tissues of a mouse model identifies miR-34a as a key regulator in SMA pathogenesisSemantic proximity Read

SMN and Gemins: ‘We are family’ … or are we?Semantic proximity Read

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read

Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stagesSemantic proximity Read

Myostatin is a negative regulator of adult neurogenesis in zebrafishSemantic proximity Read

Genomic analysis of a spinal muscular atrophy (SMA) discordant family identifies a novel mutation in TLL2, an activator of growth differentiation factor 8 (myostatin): a case report.Semantic proximity Read

Transcriptomic Characterisation of the Molecular Mechanisms Induced by RGMa During Skeletal Muscle Hyperplasia and HypertrophySemantic proximity Read

Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiationSemantic proximity Read

Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i>Semantic proximity Read

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesisSemantic proximity Read

Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye developmentSemantic proximity Read