Article

Entorhinal cortex glutamatergic and GABAergic projections bidirectionally control discrimination and generalization of hippocampal representations

2023-11-11

Abstract excerpt

Discrimination and generalization are crucial brain-wide functions for memory and object recognition that utilize pattern separation and completion computations. Circuit mechanisms supporting these operations remain enigmatic. We show lateral entorhinal cortex glutamatergic (LEC GLU ) and GABAergic (LEC GABA ) projections are essential for object recognition memory. Silencing LEC GLU during in vivo two-photon...

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Literature Corpus work: 9bd4b24a-1486-58e6-b3fb-5f0d3cd695d9
DOI: 10.1101/2023.11.08.566107

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