Article

Brusatol Sensitizes Endometrial Hyperplasia and Cancer to Progestin by Suppressing Nrf2-Tet1-AKR1C1-Mediated Progestin Metabolism

2021-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Progestin resistance is the main obstacle for the conservative therapy to maintain fertility in women with endometrial hyperplasia and cancer. Up to 30% of endometrial cancers fail to respond to progestin, a rate that has not significantly changed due to the lack of a detailed understanding of progestin resistance.<bold>Methods</bold>Cell Counting Kit-8 (CCK-8) as...

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Literature Corpus work: 9a8c905f-a4d3-58dc-a39c-20fa3c1606ef
DOI: 10.21203/rs.3.rs-427970/v1

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