Article

Simulation of model overfit in variance explained with genetic data

2019-04-10

Abstract excerpt

Two recent papers, and an author response to prior commentary, addressing the genetic architecture of human temperament and character claimed that “The identified SNPs explained nearly all the heritability expected”. The authors’ method for estimating heritability may be summarized as: Step 1: Pre-select SNPs on the basis of GWAS p<0.01 in the target sample. Step 2: Enter target sample genotypes (the pre-selected...

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Literature Corpus work: 99fc1676-1c0b-5f4a-91f5-eb3c998ae6a6
DOI: 10.1101/598904

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