Article

Like Dissolves Like? A Comprehensive Evaluation of Partial Solubility Parameters to Predict Polymer-Drug Compatibility in Ultra-High Drug Loaded Polymer Micelles

2019-04-30

Abstract excerpt

Despite decades of research, our understanding of the molecular interactions between drugs and polymers in drug loaded polymer micelles does not extend much beyond concepts such as “like-dissolves-like“ or hydrophilic/hydrophobic. However, polymer-drug compatibility strongly affects formulation properties and therefore the translation of a formulation into the clinics. Specific interactions such as hydrogen-...

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Literature Corpus work: 9931a71d-4a91-5edf-918b-f343168136d3
DOI: 10.26434/chemrxiv.8055728.v1

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