Article

Genome-context-aware discovery of antibacterial peptides from bacterial small open reading frames

2026-08-21

Abstract excerpt

Small open reading frames (sORFs) are a potentially rich, yet error-prone, source of antimicrobial-peptide (AMP) candidates: short sequences are readily prioritized by AMP classifiers but may derive from incomplete gene calls. We developed a genome-context-aware discovery workflow that separates AMP-like sequence properties from evidence for a complete, recurrent coding locus. From 649,653 RefSeq assemblies repres...

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Literature Corpus work: 98f8dcb9-14ed-536c-b138-7aa07a5e62e3
DOI: 10.64898/2026.08.17.745349

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