Article

Tissue tearing degrades optimal-transport and diffeomorphic registration of spatial transcriptomics beyond displacement magnitude: a multi-seed deformation benchmark and a supervised graph cross-attention proof-of-concept

2026-07-05

Abstract excerpt

<h4>Background</h4> Three-dimensional reconstruction from serial spatial-transcriptomics (ST) sections requires registering adjacent slices, but physical sectioning introduces tears — discontinuous, non-isometric deformations. Leading methods rely on priors that tears strain: PASTE/PASTE2 use Fused Gromov–Wasserstein optimal transport (OT), which assumes near-isometric preservation of within-slice distances, whil...

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Literature Corpus work: 9882e38a-863e-5a7a-a7bb-2abc34e01452
DOI: 10.64898/2026.06.30.735390

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