Article

Exploring the intricacies and pitfalls of the ATN framework: An assessment across cohorts and thresholding methodologies

2022-12-08

Abstract excerpt

The amyloid/tau/neurodegeneration (ATN) framework has redefined Alzheimer’s disease (AD) toward a primarily biological entity. While it has found wide application in AD research, it was so far typically applied to single cohort studies using distinct data-driven thresholding methods. This poses the question of how concordant thresholds obtained using distinct methods are within the same dataset as well as whether...

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Literature Corpus work: 97e4f234-f570-5f92-8533-ca7ded10b758
DOI: 10.1101/2022.12.06.519269

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