Article

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

2023-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Hybrid immunity to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. mRNA vaccine, BNT162b2, was dosed to induce binding antibody titers against ancestral spike, but inefficient serum virus neutralization of ancestral SARS-CoV-2 or variants of concern (Vo...

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Literature Corpus work: 97c2fb85-8e5c-5c43-8a6b-64622db42cc9
DOI: 10.1101/2023.05.22.541294

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