Article
Timing and localization of human dystrophin isoform expression provide insights into the cognitive phenotype of Duchenne muscular dystrophy.
Scientific reports - 3 Oct 2017
Doorenweerd Nathalie, Mahfouz Ahmed, van Putten Maaike, Kaliyaperumal Rajaram, T' Hoen Peter A C, Hendriksen Jos G M, Aartsma-Rus Annemieke M, Verschuuren Jan J G M, Niks Erik H, Reinders Marcel J T, Kan Hermien E, Lelieveldt Boudewijn P F
Abstract excerpt
Duchenne muscular dystrophy (DMD) is a muscular dystrophy with high incidence of learning and behavioural problems and is associated with neurodevelopmental disorders. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across human brain development, using unique transcriptomic data from Allen Human...
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