Article

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

2017-12-21

Abstract excerpt

<h4>Summary</h4> The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we present a new machine learning technique – Subtype and Stage Inference (SuStaIn) – able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from wide...

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Literature Corpus work: 953e1488-d6a1-55e0-a92e-dfa877e35661
DOI: 10.1101/236604

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