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Long non-coding RNAs and autophagy: dual drivers of Hepatocellular carcinoma progression

11 Aug 2025

Abstract excerpt

Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality worldwide, is characterized by poor prognosis, high recurrence rates, and limited responsiveness to current therapies. Autophagy, a conserved catabolic pathway essential for cellular homeostasis, plays a paradoxical role in HCC, acting as a tumor suppressor during initiation but promoting survival and progression in advanced stages. Long...

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PMID: 40789840
DOI: 10.1038/s41420-025-02667-7

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