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Interplay between Tumor Mutational Burden and Mutational Profile and its effect on overall survival: A Post Hoc Analysis of Metastatic Patients Treated with Immune Checkpoint Inhibitors

2022-04-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Solid tumors harboring tumor mutational burden (TMB) ≥ 10 mutations per megabase (mut/Mb) received agnostic approval for pembrolizumab. However, TMB cut-off alone is not a predictor of overall survival (OS). This work aims to analyze the somatic mutational profile’s influence in the outcomes of patients with TMB-high tumors treated with immune checkpoint inhibitors (ICIs). <h4>Me...

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Literature Corpus work
951dc268-799a-5667-9a03-2c7b2dc16823
DOI
10.1101/2022.04.10.22273664
Open publication

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Interplay between Tumor Mutational Burden and Mutational Profile and its effect on overall survival: A Post Hoc Analysis of Metastatic Patients Treated with Immune Checkpoint InhibitorsDOI 10.1101/2022.04.10.22273664
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