An Exploratory Analysis of Essential Tremor and Associated Phenotypes

Abstract excerpt

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a three-part study to investigate the genetic basis of ET in relation to co-occurring phenotypes, aiming to assess causal directionality and to clarify phenotypic heterogeneity. First, we...

Topics

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• Aged
• Essential Tremor
• Genetic Pleiotropy
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

9506d79c-586b-5e2b-8cca-de12edcb77a0

DOI

10.64898/2025.12.16.25342380