Article

Prioritising Functional Noncoding Variants via eRNA Post-transcriptional Interaction Maps in Human Samples

2025-08-01

Abstract excerpt

Noncoding variants and mutations outnumber their coding counterparts but remain challenging to interpret functionally. We present TranCi, a method that prioritises human genetic variations by integrating enhancer RNA (eRNA) expression with eRNA-mRNA interactome maps. By linking variant-associated changes in eRNA to downstream gene regulation, TranCi captures functional effects missed by sequence-based or chromatin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94a156f9-6bc4-5de5-a5db-ce8952373f9b
DOI: 10.1101/2025.07.31.667983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prioritising Functional Noncoding Variants via eRNA Post-transcriptional Interaction Maps in Human SamplesDOI 10.1101/2025.07.31.667983Read

FIRE: functional inference of genetic variants that regulate gene expression.Semantic proximity Read

Predicting the regulatory impacts of noncoding variants on gene expression through epigenomic integration across tissues and single-cell landscapes.Semantic proximity Read

Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.Semantic proximity Read

Variant Set Enrichment: An R package to Identify Dis-ease-Associated Functional Genomic RegionsSemantic proximity Read

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read

Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma.Semantic proximity Read

Principles and methods of in-silico prioritization of non-coding regulatory variants.Semantic proximity Read

Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genesSemantic proximity Read

SNPnotes: high-throughput tissue-specific functional annotation of single nucleotide variantsSemantic proximity Read

Predicting cell-type-specific non-coding RNA transcription from genome sequenceSemantic proximity Read

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease allelesSemantic proximity Read

REVA as a Well-curated Database for Human Expression-modulating VariantsSemantic proximity Read