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Article

Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses.

Journal of virology - 1 Aug 2017

Boonnak Kobporn, Matsuoka Yumiko, Wang Weijia, Suguitan Amorsolo L, Chen Zhongying, Paskel Myeisha, Baz Mariana, Moore Ian, Jin Hong, Subbarao Kanta

Abstract excerpt

We have developed pandemic live attenuated influenza vaccines (pLAIVs) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (clade 2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses were reported in Egypt, which prompted updating of the H5N1 pLAIV. We explored two strategies to generate suitable...

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Identifiers

PMID: 28490598
DOI: 10.1128/JVI.00547-17
PMCID: PMC5512263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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