ATXN2 trinucleotide repeat length correlates with risk of ALS.

doi:10.1016/j.neurobiolaging.2016.11.010

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Article

ATXN2 trinucleotide repeat length correlates with risk of ALS.

Neurobiology of aging - 1 Mar 2017

Sproviero William, Shatunov Aleksey, Stahl Daniel, Shoai Maryam, van Rheenen Wouter, Jones Ashley R, Al-Sarraj Safa, Andersen Peter M, Bonini Nancy M, Conforti Francesca L, Van Damme Philip, Daoud Hussein, Del Mar Amador Maria, Fogh Isabella, Forzan Monica, Gaastra Ben, Gellera Cinzia, Gitler Aaron D, Hardy John, Fratta Pietro, La Bella Vincenzo, Le Ber Isabelle, Van Langenhove Tim, Lattante Serena, Lee Yi-Chung, Malaspina Andrea, Meininger Vincent, Millecamps Stéphanie, Orrell Richard, Rademakers Rosa, Robberecht Wim, Rouleau Guy, Ross Owen A, Salachas Francois, Sidle Katie, Smith Bradley N, Soong Bing-Wen, Sorarù Gianni, Stevanin Giovanni, Kabashi Edor, Troakes Claire, van Broeckhoven Christine, Veldink Jan H, van den Berg Leonard H, Shaw Christopher E, Powell John F, Al-Chalabi Ammar

Abstract excerpt

We investigated a CAG trinucleotide repeat expansion in the ATXN2 gene in amyotrophic lateral sclerosis (ALS). Two new case-control studies, a British dataset of 1474 ALS cases and 567 controls, and a Dutch dataset of 1328 ALS cases and 691 controls were analyzed. In addition, to increase power, we systematically searched PubMed for case-control studies published after 1 August 2010 that investigated the...

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Identifiers

PMID: 28017481
DOI: 10.1016/j.neurobiolaging.2016.11.010
PMCID: PMC5302215

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ATXN2

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