Back to search

Article

Protocol for a pilot multi-centre, randomized controlled trial of the effect of inulin on gastrointestinal microbiota outcomes in mechanically ventilated adults: the INTESTINAL trial

2026-02-18

Abstract excerpt

<title>Abstract</title> <p>Background Critical illness results in dysbiosis defined as a reduction in diversity of commensals and colonisation with pathogenic bacteria. Dysbiosis is associated with acute and chronic inflammatory response and immune dysregulation. The gastrointestinal microbiome has a well-established immunomodulatory role via various pathways including production of short chain fatty acids (SCFA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9306e352-a963-5934-a6c7-59817523fcf9
DOI
10.21203/rs.3.rs-8897058/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Protocol for a pilot multi-centre, randomized controlled trial of the effect of inulin on gastrointestinal microbiota outcomes in mechanically ventilated adults: the INTESTINAL trialDOI 10.21203/rs.3.rs-8897058/v1
Effect of gut microbiota modulation on feeding tolerance of enterally-fed critically ill adult patients: a systematic reviewSemantic proximity
Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention studySemantic proximity
Gut <sup>3</sup> Gel as an in vitro model to investigate dietary modulation of the intestinal microbiota: An inulin supplementation case studySemantic proximity
The Gut-Lung Axis in Critical Illness: Microbiome Composition as a Pr edictor of Mortality at Day 28 in Mechanically Ventilated PatientsSemantic proximity
Optimizing Perioperative Nutrition in Elective Gastrointestinal Surgery: An ERAS-Focused Narrative ReviewSemantic proximity
Temporal Fluctuations of Gut Microbiota and Bile Acid Metabolism in Critically Ill ChildrenSemantic proximity
Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled TrialSemantic proximity
Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasisSemantic proximity
Omics-analyses of Fermented Onion pickle in Shaping Gut Microbiota and Immune Response in Women: A Community-Based Trial in PakistanSemantic proximity
Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a reviewSemantic proximity
The effect of butyrate-supplemented parenteral nutrition on intestinal defence mechanisms and the parenteral nutrition-induced shift in the gut microbiotaSemantic proximity
Does Intermittent Nutrition Enterally Normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the DINE-Normal proof-of-concept randomised parallel group studySemantic proximity
Select a neighboring publication to make it the new centre.