Article

MiR-1-3p Downregulation Delays Endochondral Ossification of the Acetabular Roof in DDH

2021-03-10

Abstract excerpt

<h4>Background: </h4> Developmental dysplasia of the hip (DDH) is a highly prevalent hip disease among children. However, its pathogenesis remains unclear. MiRNAs are important regulators in cartilage development. In previous study, miRNA high-throughput sequencing on an animal model of DDH showed a low level of miR-1-3p in the cartilage of acetabular roof (ARC), but its role in DDH pathogenesis was not addressed....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92b50c40-ff37-5421-8152-30e4cab074ff
DOI: 10.21203/rs.3.rs-281896/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-1-3p Downregulation Delays Endochondral Ossification of the Acetabular Roof in DDHDOI 10.21203/rs.3.rs-281896/v1Read

Chondrocyte suppression is mediated by miR‐129‐5p via GDF11/SMAD3 signaling in developmental dysplasia of the hipSemantic proximity Read

Developmental dysplasia of the hip: A systematic review of susceptibility genes and epigenetics.Semantic proximity Read

Molecular mechanisms and genetic factors contributing to the developmental dysplasia of the hipSemantic proximity Read

Identification of KANSL1 as a novel pathogenic gene for developmental dysplasia of the hip.Semantic proximity Read

Review of susceptibility genes in developmental dysplasia of the hip: A comprehensive examination of candidate genes and pathways.Semantic proximity Read

Human pluripotent stem cell model of multiple epiphyseal dysplasia with <i>MATN3</i> mutation identifies altered Matrix organisation and upregulation of the cholesterol biosynthesis pathwaySemantic proximity Read

Identification of key genes and molecular mechanism in hip joint capsule of patients with developmental dysplasia of the hipSemantic proximity Read

Human pluripotent stem cell model of multiple epiphyseal dysplasia with MATN3 mutation identifies altered matrix organisation and upregulation of the cholesterol biosynthesis pathway.Semantic proximity Read

Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.Semantic proximity Read

Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagySemantic proximity Read

Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.Semantic proximity Read

Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping reviewSemantic proximity Read