Article

Metabolic remodelling in hiPSC-derived myofibres carrying the m.3243A>G mutation

2024-06-13

Abstract excerpt

<h4>Summary</h4> Mutations in mitochondrial DNA cause severe multisystem disease, frequently associated with muscle weakness. The m.3243A>G mutation is the major cause of Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke Like episodes (MELAS). Experimental models that recapitulate the disease phenotype in vitro for disease modelling or drug screening are very limited. We have therefore generated hiPSC-d...

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Literature Corpus work: 926860e0-9ebe-5e78-8a8f-e2fe69d2b80d
DOI: 10.1101/2024.06.11.598565

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