Article

A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT

2019-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Next-generation DNA sequencing is currently limited by an inability to count the number of input DNA molecules. Molecular counting is particularly needed when accurate quantification is required for diagnostic purposes, such as in single-gene non-invasive prenatal testing (sgNIPT) and liquid biopsy. We developed Quantitative Counting Template (QCT) molecular counting for reconstructing the numbe...

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Literature Corpus work: 92038b48-bfc9-5142-ab66-713844520090
DOI: 10.1101/597732

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