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A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT

7 Oct 2019

Abstract excerpt

Next-generation DNA sequencing is currently limited by an inability to accurately count the number of input DNA molecules. Molecular counting is particularly needed when accurate quantification is required for diagnostic purposes, such as in single gene non-invasive prenatal testing (sgNIPT) and liquid biopsy. We developed Quantitative Counting Template (QCT) molecular counting to reconstruct the number of input...

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PMID: 31591409
DOI: 10.1038/s41598-019-50378-8

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