Article

A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy

2025-02-11

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a fatal genetic disorder causing the thickening of ventricular walls in the heart muscle. While certain mutations in cardiac myosin deregulate ATPase activity, the pathology mechanism of most HCM mutations is not known. Here, by designing a fluorescent reporter to monitor myosin folding in cells, we uncovered a distinct class of HCM mutations that cause graded defects in myosin...

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Identifiers and source

Literature Corpus work: 90bc0342-8dea-50e4-89bc-900264a28c03
DOI: 10.1101/2025.02.10.636595

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