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Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells

2018-08-06

Abstract excerpt

<h4>Highlights</h4> H/R induces autophagy and Nrf2 in tumoral and primary trophoblast cells. Melatonin inhibits autophagy and Nrf2 under H/R, inducing BeWo cell death. Melatonin increases autophagy and Nrf2 under H/R conditions, promoting primary villous trophoblast cells survival. Hypoxia/reoxygenation (H/R) induces oxidative damage and apoptosis. These consequences activate autophagy, which degrades damaged cel...

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Identifiers and source

Literature Corpus work
8f18fc07-3ff3-5470-ad0f-a5892bb42054
DOI
10.1101/385948
Open publication

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