Article

Global increase in circRNA levels in myotonic dystrophy

2018-12-07

Abstract excerpt

Splicing aberrations induced as a consequence of the sequestration of MBNL splicing factors on the DMPK transcript, which contains expanded CUG repeats, present a major pathomechanism of myotonic dystrophy type 1 (DM1). As MBNLs may also be important factors involved in the biogenesis of circular RNAs (circRNAs), we hypothesized that the level of circRNAs would be decreased in DM1. To test this hypothesis, we sele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8eb377be-5d49-5917-928a-fe21388fb65d
DOI: 10.1101/489070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Global increase in circRNA levels in myotonic dystrophyDOI 10.1101/489070Read

Dysregulation of circular RNAs in myotonic dystrophy type 1Semantic proximity Read

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stageSemantic proximity Read

Circular Smad1-Encoded Polypeptide Regulates MyogenesisSemantic proximity Read

Regulation of Toxic RNA Foci and Mutant <i>DMPK</i> Transcripts: Role of MBNL Proteins and RNA Decay PathwaysSemantic proximity Read

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type ISemantic proximity Read

MicroRNA-Based Therapeutic Perspectives in Myotonic DystrophySemantic proximity Read

The hallmarks of myotonic dystrophy type 1 muscle dysfunctionSemantic proximity Read

Co-opting MBNL-dependent alternative splicing cassette exons to control gene therapy in myotonic dystrophySemantic proximity Read

Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesisSemantic proximity Read

Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1Semantic proximity Read

Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic DystrophySemantic proximity Read

The CTG repeat expansion size correlates with the splicing defects observed in muscles from myotonic dystrophy type 1 patientsSemantic proximity Read