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Article

A novel haplotype of spinocerebellar ataxia type 6 contributes to the highest prevalence in western Japan.

Neuroscience letters - 25 Mar 2004

Terasawa Hideo, Oda Masaya, Morino Hiroyuki, Miyachi Takafumi, Izumi Yuishin, Maruyama Hirofumi, Matsumoto Masayasu, Kawakami Hideshi

Abstract excerpt

The highest prevalence rate of spinocerebellar ataxia type 6 (SCA6) in the worldwide population is in the Chugoku and Kansai areas of Western Japan, but the reason of this geographic characteristics is unclear. We investigated the predisposing haplotypes and their geographic distribution. Genotyping of five microsatellite markers and three single nucleotide polymorphisms linked to the CACNA1A gene in 150 Japanese...

Topics

Adult
Aged
Asian People
Calcium Channels
Chi-Square Distribution
Haplotypes
Humans
Japan
Microsatellite Repeats
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prevalence

Spinocerebellar Ataxias

Source

Identifiers

PMID: 15026160
DOI: 10.1016/j.neulet.2004.01.007

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