Article

Identification of A Novel FRK-ROS1 Fusion Variant in Advanced Non-Small Cell Lung Cancer with Brain Metastases and Remarkable Response to Crizotinib

2021-10-27

Abstract excerpt

<title>Abstract</title> <p><italic>ROS1</italic>-rearranged non-small cell lung cancer (NSCLC) is a subset of NSCLC patients with unique malignant behavior and clinical course. Crizotinib, a multi-targeted <italic>ALK</italic>/<italic>ROS1</italic>/<italic>MET </italic>tyrosine kinase inhibitor (TKI), has promising significant activity in NSCLC with <italic>ROS1</italic>-rearrangement. The next-generation sequenc...

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Literature Corpus work: 8e54eb0e-66e5-5acd-b21e-df9bfff4550e
DOI: 10.21203/rs.3.rs-989538/v1

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