Article
A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools.
Nature protocols - 1 Mar 2026
Lujumba Ibra, Adam Yagoub, Ziaei Jam Helyaneh, Isewon Itunuoluwa, Monnakgotla Nomakhosazana, Li Yang, Onyido Blessing, Fredrick Kakembo, Adegoke Faith, Emmanuel Jerry, Adeyemi Jumoke, Ibitoye Olajumoke, Owusu-Ansah Samuel, Akanle Matthew Boladele, Joseph Habi, Nsubuga Mike, Galiwango Ronald, Okitwi Martin, Magdalene Namuswe, Walter Odur, Mngadi Zama, Adebiyi Marion, Oyelade Jelili, Nel Melissa, Jjingo Daudi, Gymrek Melissa, Adebiyi Ezekiel
Abstract excerpt
Tandem repeats (TRs) are highly variable loci in the human genome that are linked to various human phenotypes. Accurate and reliable genotyping of TRs is important in understanding population TR variation dynamics and their effects in TR-trait association studies. In this protocol, we describe how to generate high-quality consensus TR genotypes for population genomics studies. In particular, we detail steps to:...
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