Article

Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential Therapeutics

2020-04-20

Abstract excerpt

Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The case fatality rate is significantly higher in older patients and those with diabetes, cancer or cardiovascular disorders. The human proteins, angiotensin-converting enzyme 2 (ACE2) and basigin (BSG), are involved in high-confidence host-pathogen interactions with proteins f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d928e8c-3807-54b5-93c0-5e5ff41bfcd7
DOI: 10.26434/chemrxiv.12136470.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential TherapeuticsDOI 10.26434/chemrxiv.12136470.v1Read

Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential TherapeuticsSemantic proximity Read

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19Semantic proximity Read

Identification of pulmonary comorbid diseases network based repurposing effective drugs for COVID-19Semantic proximity Read

ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk FactorsSemantic proximity Read

ACE2 interaction networks in COVID-19: a physiological framework for prediction of outcome in patients with cardiovascular risk factorsSemantic proximity Read

COVID-19: A Drug Repurposing and Biomarker Identification by Using Comprehensive Gene-Disease Associations through Protein-Protein Interaction Network AnalysisSemantic proximity Read

Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactomeSemantic proximity Read

Impact of Comorbidity on Severity of Covid-19 Patients: A Network of Target Coding Genes PerspectiveSemantic proximity Read

Looking for pathways related to COVID-19 phenotypes: Confirmation of pathogenic mechanisms by SARS-CoV-2 - Host interactomeSemantic proximity Read

Potential Genes Associated with COVID-19 and Comorbidity.Semantic proximity Read

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infectionSemantic proximity Read

Identification of COVID‐19 Infection‐Related Human Genes Based on a Random Walk Model in a Virus–Human Protein Interaction NetworkSemantic proximity Read