Article

Personalized modeling of the human gut microbiome reveals distinct bile acid deconjugation and biotransformation potential in healthy and IBD individuals

2017-12-04

Abstract excerpt

The human gut microbiome performs important functions human health and disease. Intestinal microbes are capable of deconjugation and biotransformation of human primary bile acids to secondary bile acids. Alterations of the bile acid pool as a result of microbial dysbiosis have been linked to multifactorial diseases, such as inflammatory bowel disease (IBD). Constraint-based modeling is a powerful approach for the...

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Literature Corpus work: 8d4fa934-167c-5c45-ad2e-fbcd53a0bbba
DOI: 10.1101/229138

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