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Genome-scale metabolic modelling of human gut microbes to inform rational community design

20 Jul 2025

Abstract excerpt

The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome therapeutically, its effectiveness is often limited by the microbial community's complexity and individual variability in microbiome functionality. We utilized genome-scale...

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PMID: 40685566
DOI: 10.1080/19490976.2025.2534673

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