Article
Sex differences in immune function and disease risk are not easily explained by an evolutionary mismatch
2024-02-16
Abstract excerpt
The Pregnancy Compensation Hypothesis (PCH) posits that sex differences in the mammalian immune system reflect the effects of selection on female immunity during pregnancy, during which increased immunomodulation is required to reduce immune responses to the fetus, while maintaining the ability to respond to pathogens. In humans, fewer pathogens and lower parity in urban, industrialized environments has been sugge...
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Identifiers and source
- Literature Corpus work
- 8d020df6-ff8b-5f7d-b8ef-7a465ca7ae5e
- DOI
- 10.1101/2024.02.13.580011