Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer.

doi:10.1007/s00210-026-05591-4

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Article

Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Sept 2026

Liu Quanxia, Yu Dong, Qiao Lijiao, Wang Nan, Fan Weining, Wei Tingting, Tian Zhiqiang, Ma Xiaoqiang, Xie Xiaoliang

Abstract excerpt

To investigate the potential molecular mechanisms underlying aspartame (APM)-induced malignant phenotypic changes in colorectal cancer (CRC). Candidate targets of APM were identified by integrating the ChEMBL, SwissTargetPrediction, and SEA databases. Differential expression analysis was performed using transcriptomic data from The Cancer Genome Atlas (TCGA) CRC cohort, followed by weighted gene co-expression...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Molecular Docking Simulation
Aspartame
Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Epithelial-Mesenchymal Transition

Oxidative Stress

Cell Line, Tumor

Gene Expression Regulation, Neoplastic

Molecular Dynamics Simulation

Sweetening Agents

Source

Open in PubMed

Identifiers

PMID: 42319418
DOI: 10.1007/s00210-026-05591-4

Genes

ITGA2
MMP3
BACE2
CAPN2
SLC7A5
CCK
SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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