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Article

Biochemical Characterization of Sperm Agglutination Antigen-1, a Human Sperm Surface Antigen Implicated in Gamete Interactions1

1 Nov 1997

Abstract excerpt

The anti-sperm monoclonal antibody (mAb) S19 was previously demonstrated to agglutinate human spermatozoa, inhibit sperm penetration of cervical mucus, and inhibit sperm-zona pellucida binding. These results implicated the cognate S19 antigen, designated sperm agglutination antigen-1 (SAGA-1), in gamete interactions and identified SAGA-1 as an attractive candidate for immunocontraceptive development. In the...

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PMID: 9369181
DOI: 10.1095/biolreprod57.5.1136

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