Article

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

2021-03-18

Abstract excerpt

<title>Abstract</title> <p>Mouse models are critical in pre-clinical studies of cancer therapy, allowing dissection of mechanisms through chemical and genetic manipulations that are not feasible in the clinical setting. In studies of the tumour microenvironment (TME), novel highly multiplexed imaging methods can provide a rich source of information. However, the application of such technologies in mouse tissues i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c1b44e2-0e4b-53b6-886f-c407e714cd4d
DOI: 10.21203/rs.3.rs-301541/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflowDOI 10.21203/rs.3.rs-301541/v1Read

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometrySemantic proximity Read

Imaging Mass Cytometry (IMC) as a Tool to Characterize Circulating Tumor Cells (CTCs) in Preclinical Mouse ModelsSemantic proximity Read

Development of a high dimensional imaging mass cytometry panel to investigate spatial organization of tissue microenvironment in formalin-fixed archival clinical tissuesSemantic proximity Read

Multi-modal image analysis for large scale cancer tissue studies within IMMUcanSemantic proximity Read

Mistic: an open-source multiplexed image t-SNE viewerSemantic proximity Read

IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic dataSemantic proximity Read

ImmuNet: A Segmentation-Free Machine Learning Pipeline for Immune Landscape Phenotyping in Tumors by Muliplex ImagingSemantic proximity Read

Sparse-spectral microendoscopy for real-time visualization of tumor cell phenotype and microenvironment spatial heterogeneity <i>in vivo</i>Semantic proximity Read

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trialSemantic proximity Read

A Computational Workflow for Cell Line Profiling by Imaging Mass Cytometry.Semantic proximity Read

Advanced Quantification Pipeline Reveals New Spatial and Temporal Tumor Characteristics in Preclinical Multiple MyelomaSemantic proximity Read

NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to in-Vivo ImagesSemantic proximity Read