Article

Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases

2025-11-01

Abstract excerpt

<title>Abstract</title> <p>Immune responses in systemic autoinflammatory disease (SAID) were investigated by multi-omics analysis, integrating RNA expression and proteomic data. By identifying the top 10 co-expressed transcripts of IL1B and BLNK, we demonstrated the simultaneous activation of pro- and anti-inflammatory pathways in 338 SAID patients, with less activation in 68 negative controls. Our findings highl...

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Literature Corpus work: 8c0d2d94-5c69-52bb-a227-a30ac15acdb5
DOI: 10.21203/rs.3.rs-6173310/v1

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