Article

Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among children

2024-02-14

Abstract excerpt

It has been postulated from a combination of evidence that a sudden increase in COVID-19 cases among pediatric patients after onset of the Omicron wave was attributed to a reduced requirement for TMPRSS2-mediated entry in pediatric airways with lower expression levels of TMPRSS2. Epidemic strains were isolated from the indigenous population in an area, and the levels of TMPRSS2 required for Delta and Omicron varia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bb3f7c7-739a-53b7-9bfd-2c342f4a85e0
DOI: 10.1101/2024.02.13.24302758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among childrenDOI 10.1101/2024.02.13.24302758Read

Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children.Semantic proximity Read

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cellsSemantic proximity Read

Burden of Pediatric SARS-CoV-2 Hospitalizations during the Omicron Wave in GermanySemantic proximity Read

SARS-CoV-2 Omicron variant replication in human respiratory tract ex vivoSemantic proximity Read

Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines.Semantic proximity Read

Clinical Characteristics of SARS-CoV-2 Omicron Infection in Children under One YearSemantic proximity Read

Epidemiological Characterization of SARS-CoV-2 Variants in Children Over the Four COVID-19 Waves and Correlation with Clinical PresentationSemantic proximity Read

Preliminary clinical characteristics of Pediatric Covid-19 cases during the ongoing Omicron XBB.1.16 driven surge in a north Indian citySemantic proximity Read

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsSemantic proximity Read

Omicron variant genome evolution and phylogenetics.Semantic proximity Read

SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entrySemantic proximity Read

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airwaysSemantic proximity Read