Article

A multimodal AI model for modeling the genetic risk factor of Alzheimer’s disease

2026-04-15

Abstract excerpt

The apolipoprotein E ε 4 (APOE4) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), the most common form of dementia. APOE4 carriers exhibit cerebrovascular and metabolic dysfunction, structural brain alterations, and gut microbiome changes decades before the onset of clinical symptoms. Better understanding of the early manifestion of these physiological changes is critical for d...

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Literature Corpus work: 8a84109e-3364-5c40-bf05-a7149ab9b87e
DOI: 10.64898/2026.04.13.26350803

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