Article

DDX3X mediates EGFR-TKI resistance through VEGFR signaling

2021-12-01

Abstract excerpt

Although epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are remarkably effective against non-small-cell lung cancer (NSCLC) with EGFR -activating mutations, lung cancer cells acquire resistance to EGFR-TKIs without exception. Several mechanisms of EGFR-TKI resistance have been reported, but there are many aspects that remain to be clarified. We previously identified DDX3X as an immunogen...

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Literature Corpus work: 8a7318e6-557a-5531-aeca-5f05189ca1fa
DOI: 10.21203/rs.3.rs-1073662/v1

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